mask
Subscribe
  • Open Access

    All research articles in the journals are open access and free world wide readership/ access to all articles immediately upon publication. Gerf Bulletin of Biosciences commits to maintain open acce...

  • Fast Track Publication

    GERF Bulletin of Biosciences offers Fast Track online publication of your manuscript dramatically reduces the time that your targeted readers/researchers must wait to see your research.

Current Issue
Manuscript Details
Vol. 1 Issue 1 December 2010
Research Article
Vitamin E provides protection against in vitro oxidative stress due to pesticide (Chlorpyrifos and Endosulfan) in goat RBC
Ronika Saxena and Poonam Garg
Download Matrix
Abstract:

Research Article

 

GERF Bulletin of Biosciences

December 2010, 1(1): 1-6

 

Vitamin E provides protection against in vitro oxidative stress due to pesticide (Chlorpyrifos and Endosulfan) in goat RBC

 

Ronika Saxena and Poonam Garg*

 

Department of Chemistry, Bareilly College, Bareilly -243 005 (UP), India

 

*Corresponding author: mailme_poonamgarg@rediffmail.com

 

Abstract

 

Over the centuries, humans have developed many ingenious methods in their attempts to control herbs, weeds, insects, invertebrates and microorganisms that constantly threatened the supply of food and fibre as well as posed a threat to public health. The aim of present study was to find out the protective nature of antioxidant property of vitamin E in against chlorpyrifos and endosulfan toxicity. Erythrocytes were collected from healthy goat and exposed to 10ppm chlorpyrifos and endosulfan pesticide individually and also along with vitamin E treatment. Results showed endosulfan was more toxic in comparison of chlorpyrifos. Activity of Superoxide dismutase (SOD) and Catalase significantly decreased and lipid peroxidation (LPO) and Glutathione S-transfarase (GST) was increased in comparison of control value. The result of the present study suggests that vitamin E is an effective antioxidant for chlorpyrifos and endosulfan pesticide toxicity in reducing oxidative stress burden. It can be concluded that organophosphate chlorpyrifos and endosufan insecticides induced oxidative stress and lipid peroxidation level in mammalian erythrocytes (RBCs) and conjugation and supplementation of vitamin E or in combination has amelionated these effects.

 

© 2010 Saxena and Garg; licensee Green Earth Research Foundation. This article distributed under terms of Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/)

GERF, Green Earth Research Foundation, GERFBB, Open access, Biosciences, No publication charges, Fast track publication, Online First articles, Biological, Chemical, Life science, Natural science, Clinical sciences, biology, cell biology, molecular biology, microbiology, immunology, genetics, biotechnology, plant science, pathology, histopathology, pest and disease management, physiology, cancer biology, molecular medicine, bioinformatics, fermentation technology, IPR, Intellectual Property Rights
mask