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Vol. 2 Issue 1 June 2011
Research Article
Identification, synthesis and spectral characterization of impurities in process development of Escitalopram
Srinivas Gangula, Naveen Kumar Kolla, Chandrashekar R. Elati, Ashok Dongamanti and Rakeshwar Bandichhor
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Research article


June 2011, 2(1):1-5

GERF Bulletin of Biosciences


Identification, synthesis and spectral characterization of impurities in process development of Escitalopram


Srinivas Gangula1, Naveen Kumar Kolla1, Chandrashekar R. Elati1, Ashok Dongamanti2* and Rakeshwar Bandichhor1


1Integrated Product Development, Innovation Plaza, Dr.Reddy’s Laboratories Ltd, Bachupalli, Qutubullapur, Rangareddy District-72, Andhra Pradesh, India.

2Department of Chemistry, Osmania University, Hyderabad-07, India


*Corresponding authors:




Synthesis and identification of five process-related impurities of escitalopram are described. Structures of all the four impurities were identified by employing LC-MS (liquid chromatography-mass spectrometry) and subsequently characterized by other spectral techniques e.g. IR and NMR. Based on the spectral data, the structures of these impurities were characterized as 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxamide 4, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxylicacid 5, N-{3-[5-cyano-1-(4-fluorophenyl)]-1,3-dihydro-2-benzofuran-1-yl]propyl}formamide 6 and 1-(4-fluorophenyl)-1-[3-(methyl amino)propyl]-1,3-dihydro-2-benzofuran-5-carbonitrile 7.


© 2011 Gangula et al.; licensee Green Earth Research Foundation. This article distributed under terms of Creative Commons Attribution License (

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