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Manuscript Details
Vol. 2 Issue 1 June 2011
Research Article
Identification, synthesis and spectral characterization of impurities in process development of Escitalopram
Srinivas Gangula, Naveen Kumar Kolla, Chandrashekar R. Elati, Ashok Dongamanti and Rakeshwar Bandichhor
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Abstract:

Research article

 

June 2011, 2(1):1-5

GERF Bulletin of Biosciences

 

Identification, synthesis and spectral characterization of impurities in process development of Escitalopram

 

Srinivas Gangula1, Naveen Kumar Kolla1, Chandrashekar R. Elati1, Ashok Dongamanti2* and Rakeshwar Bandichhor1

 

1Integrated Product Development, Innovation Plaza, Dr.Reddy’s Laboratories Ltd, Bachupalli, Qutubullapur, Rangareddy District-72, Andhra Pradesh, India.

2Department of Chemistry, Osmania University, Hyderabad-07, India

 

*Corresponding authors: ashokdou@gmail.com

 

Abstract

 

Synthesis and identification of five process-related impurities of escitalopram are described. Structures of all the four impurities were identified by employing LC-MS (liquid chromatography-mass spectrometry) and subsequently characterized by other spectral techniques e.g. IR and NMR. Based on the spectral data, the structures of these impurities were characterized as 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxamide 4, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carboxylicacid 5, N-{3-[5-cyano-1-(4-fluorophenyl)]-1,3-dihydro-2-benzofuran-1-yl]propyl}formamide 6 and 1-(4-fluorophenyl)-1-[3-(methyl amino)propyl]-1,3-dihydro-2-benzofuran-5-carbonitrile 7.

 

© 2011 Gangula et al.; licensee Green Earth Research Foundation. This article distributed under terms of Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/

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